The only time I use them? Against Tyranids. Venom Cannons can ONLY cause glancing hits. With the holofield and spirit stones you can survive most (and even ignore some) glancing hits. Their speed and agility should keep them out of range of any other weapons. The other plus is that even basic Vyper weaponry (the Shuriken Cannon) is effective against most bugs. The strategy is even more effective if the Tyranid player has only a few Venom Cannons and the Ulthwe field a large number of tough (Wraithlord) and/or armoured (Falcons, Fire Prisms, War Walkers, Wave Serpents...) targets.
If you want to see a Hive Tyrant's head spin around like an insectoid exorcist, just give it a dozen horribly be-weaponed targets to shoot at.
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